Baby Names Gender-Neutral Names Meaning of the Name Guadelupe Updated January 21, 2026 by Jennifer M. Guadelupe Gender: Neutral Origin: Spanish Meaning: Wolf Valley ♥ Add to my Namelist What is the meaning of the name Guadelupe? The name Guadelupe is primarily a gender-neutral name of Spanish origin that means Wolf Valley. People who like the name Guadelupe also like: Dezi, Antonio, Enrique, Mikasi, Mingan, Jose, Conner, Chloe, Charlotte, Dulce, Bella, Elana, Esmerelda, Sohalia Names like Guadelupe: Guadalupe, Godelieve Stats for the Name Guadelupe Guadelupe is currently not in the top 100 on the Baby Names Popularity Charts Guadelupe is currently not ranked in U.S. births