Baby Names Boy Names Meaning of the Name Santo Updated January 22, 2026 by Jennifer M. Santo Gender: Male Origin: Spanish Meaning: Holy ♥ Add to my Namelist What is the meaning of the name Santo? The name Santo is primarily a male name of Spanish origin that means Holy. People who like the name Santo also like: Santino, Cesar, Joaquin, Santiago, Cosmo, Ponce, Dante, Brandice, Braylin, Flo, Marlee, Amberlin, Jadyn, Jaelyn Names like Santo: Samad, Smith, Skanawati, Santa, Shawnda, Shenandoah, Suniti, Synott, Samant, Shaunta, Sandy, Shanda, Saint, Sondo, Shanta, Sigmund, Samhita , Samantha, Shanti, Sunday, Schmidt, Smitty, Sunita, Shandi, Sontee, Shinta, Siyanda, Suyuntu, Sioned, Suewinda Stats for the Name Santo Santo is currently not in the top 100 on the Baby Names Popularity Charts Santo is currently not ranked in U.S. births